This comprehensive book examines a range of examples, prepared by a diverse group of academic and industry practitioners, which demonstrate how cloud-based simulation is being extensively used across many disciplines, including cyber-physical systems engineering. This book is a compendium of the state of the art in cloud-based simulation that instructors can use to inform the next generation. It highlights the underlying infrastructure, modeling paradigms, and simulation methodologies that can be brought to bear to develop the next generation of systems for a highly connected society. Such systems, aptly termed cyber-physical systems (CPS), are now widely used in e.g. transportation systems, smart grids, connected vehicles, industrial production systems, healthcare, education, and defense.